Publications by authors named "S Muhammadnejad"
Human-derived tumor models are essential for preclinical development of new anticancer drug entities. Generating animal models bearing tumors of human origin, such as patient-derived or cell line-derived xenograft tumors, is dependent on immunodeficient strains. Tumor-bearing immunodeficient mice are susceptible to developing unwanted disorders primarily irrelevant to the tumor nature; and if get involved with such disorders, reliability of the study results will be undermined, inevitably confounding the research in general.
View Article and Find Full Text PDFIntroduction: Gastric cancer is one of the most commonly known malignancies and is the fifth cancer-related death globally. Whereas natural killer (NK) cells play a critical role in tumor elimination; therefore, adoptive NK cell therapy has become a promising approach in cancer cytotherapy. Hence, this study investigated the chemo-immune cell therapy in MKN-45 derived xenograft gastric cancer model.
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- This study explores the potential to isolate and enhance WT1-reactive T cells from the blood of healthy individuals and Wilms tumor patients to combat WT1-expressing tumor cells.
- Researchers used a process involving WT1 peptide stimulation and immunomagnetic separation to enrich these T cells and tested their ability to kill Wilms tumor cells (WiTu cells) compared to standard chemotherapy.
- The results indicated that T cells from Wilms tumor patients showed higher activity against tumor cells, demonstrating over 50% lysis in optimal conditions and suggesting that these WT1-reactive T cells could be a promising approach for treating Wilms tumors through immunotherapy.
Objectives: Intolerable side effects and resistance to chemotherapeutic drugs have encouraged scientists to develop new methods of drug combinations with fewer complications. This study aimed to investigate the synergistic effects of quercetin and imatinib encapsulated in chitosan nanoparticles on cytotoxicity, apoptosis, and cell growth of the K562 cell line.
Materials And Methods: Imatinib and quercetin were encapsulated in chitosan nanoparticles and their physical properties were determined using standard methods and SEM microscope images.
Objective: A preclinical study was designed to evaluate the effects of adoptively transferred cytokine-induced killer (CIK) cells on colorectal adenocarcinoma.
Methods: Forty NOG mice bearing HT-29 xenograft tumors were developed and equally divided into 2 groups of treatment and control. The mice in the treatment group received cumulatively 40-60 × 10 CIK cells in four divided doses.