Publications by authors named "S Mufti"
Article Synopsis
- * It found that childhood challenging behaviors were significant predictors of later mental health outcomes, overshadowing the impacts of autism and ADHD when challenging behaviors were accounted for.
- * The research highlights the importance of early intervention strategies addressing challenging behaviors in children, particularly for those with co-occurring conditions like ADHD and autism, to improve adult mental health outcomes.
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies.
View Article and Find Full Text PDFThe Seattle Alzheimer’s Disease Brain Cell Atlas (SEA-AD) is a multifaceted open data resource designed to identify cellular and molecular pathologies that underlie Alzheimer’s disease. Integrating neuropathology, single cell and spatial genomics, and longitudinal clinical metadata, SEA-AD is a unique resource for studying the pathogenesis of Alzheimer’s and related dementias.
View Article and Find Full Text PDFWe present an enhancer AAV toolbox for accessing and perturbing striatal cell types and circuits. Best-in-class vectors were curated for accessing major striatal neuron populations including medium spiny neurons (MSNs), direct and indirect pathway MSNs, as well as Sst-Chodl, Pvalb-Pthlh, and cholinergic interneurons. Specificity was evaluated by multiple modes of molecular validation, three different routes of virus delivery, and with diverse transgene cargos.
View Article and Find Full Text PDFIntroduction: Because of wide heterogeneity in the epidemiology of heart failure among different populations, it is imperative to establish population-specific databases.
Aims And Objectives: To describe the clinical profile, treatment patterns, and outcomes of heart failure patients admitted to our tertiary care hospital.
Material And Methods: The study was a prospective observational study conducted over two years at our tertiary care hospital.