Publications by authors named "S Muenst"
Article Synopsis
- The study investigates the role of BRCA promoter methylation in triple-negative breast cancer (TNBC), emphasizing its potential as an alternative to rare somatic BRCA mutations, particularly in relation to the effectiveness of PARP inhibitors.
- Researchers analyzed BRCA promoter methylation in breast cancer metastases using advanced methylation profiling and tested tumor organoids derived from these tumors for their response to PARP inhibitors.
- The findings suggest that while BRCA promoter hypermethylation is rare in metastatic breast cancer, it is preserved in xenograft models and may serve as a valuable indicator for targeted PARP inhibitor therapy.
25 to 50% of patients suffering from colorectal cancer develop liver metastases. The incidence of regional lymph node (LN) metastases within the liver is up to 14%. The need for perihilar lymph node dissection (LND) is still a controversial topic in patients with colorectal liver metastases (CRLM).
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- The incidence of hepatocellular carcinoma (HCC) is rising in the western world, and this study compares complications and survival rates between two liver resection types: anatomic (ALR) and non-anatomic (NALR).
- The research involved 298 patients treated at specialized centers in Switzerland and Germany from 2009 to 2020 and indicated that ALR had fewer post-operative complications compared to NALR.
- Despite the differences in complications, there were no significant variations in recurrence-free survival (RFS) and overall survival (OS) rates between the two resection types, and cirrhosis did not affect these outcomes.
Background: The removal of common bile duct stones by endoscopic retrograde cholangiopancreatography (ERCP) shows excellent results with low complication rates and is therefore considered a gold standard. However, in case of stones non-removable by ERCP, surgical extraction is needed. The surgical approach is still controversial and clinical guidelines are missing.
View Article and Find Full Text PDFImportance: The role of axillary lymph node dissection (ALND) to determine nodal burden to inform systemic therapy recommendations in patients with clinically node (cN)-positive breast cancer (BC) is currently unknown.
Objective: To address the association of ALND with systemic therapy in cN-positive BC in the upfront surgery setting and after neoadjuvant chemotherapy (NACT).
Design, Setting, And Participants: This was a prospective, observational, cohort study conducted from August 2018 to June 2022.