Analysis of education and previous nursing experience of certified PNPs in the United States.

Background: Educational programs to prepare nurse practitioners (NPs) were historically built upon foundational nursing experience. Originally prepared as certificate programs in 1965, the educational requirements for nurse practitioners (NPs) rapidly shifted from certificate programs to the Master's degree (DellaBella, 2015; Fairman, 2008). As Doctor of Nursing Practice (DNP) degree programs increase in number, it is unknown whether this foundational nursing experience has changed, or if it differs by certification type for pediatric nurse practitioners (PNPs).

Evaluation of a semi-automated approach for FDG PET image analysis for routine clinical application in patients with multiple myeloma.

Background: FDG PET/CT is a tool for assessing response to therapy in various cancers, and may provide an earlier biomarker of clinical response. We developed a novel semi-automated approach for analyzing FDG PET/CT images in patients with multiple myeloma (MM) to standardize FDG PET application.

Methods: Patients (n = 8) with relapsed/refractory MM from the Phase 2 study (NCT02899052) of venetoclax plus carfilzomib and dexamethasone underwent FDG PET/CT at baseline and up to two timepoints during treatment.

Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report.

Background: A genetically engineered pig cardiac xenotransplantation was done on Jan 7, 2022, in a non-ambulatory male patient, aged 57 years, with end-stage heart failure, and on veno-arterial extracorporeal membrane oxygenation support, who was ineligible for an allograft. This report details our current understanding of factors important to the xenotransplantation outcome.

Methods: Physiological and biochemical parameters critical for the care of all heart transplant recipients were collected in extensive clinical monitoring in an intensive care unit.

"They Don't Understand Us, but We Have to Understand Them": Interrogating the Making of Interdisciplinary Research in Chilean Climate Science.

In this article, we examine the ways in which the notion of interdisciplinarity was understood, implemented and experienced by researchers at a government-funded Chilean climate research centre. Our multi-site ethnography, consisting of interviews, participant observations, and document analysis, was motivated by three key aims. First, to generate an inductive, multi-faceted picture of the lived meaning of "interdisciplina" at the Centre; second, to explore whether and to what extent the "peripheral" features of the research context would exacerbate the challenges associated with practicing interdisciplinarity, and third, to see whether frictions between disciplines at the Centre could be considered productive "dissonances" in Stark's sense of the term.

Explaining the climate sensitivity of junction geometry in global river networks.

Rivers form characteristic branching patterns as they drain landscapes. Past work has shown that the angles formed between confluent channels at river junctions vary with climate aridity-but why this occurs is contested. We show how this climate sensitivity can be explained by the principle that river networks self-organize toward "optimal" configurations that minimize the hydraulic expenditure of energy.