A randomised, single-blind comparison of high-level disinfectants for flexible nasendoscopes.

Objectives: To compare the microbiological efficacy, turnaround time, cost, convenience, and patient and user tolerance of Tristel Trio Wipes, PeraSafe solution and Cidex OPA solution for the high-level disinfection of flexible nasendoscopes.

Methods: Flexible nasendoscopes were used in routine clinical encounters. They were then disinfected with one of the three disinfectant methods.

Focal and nonfocal prospective memory performance in very mild dementia: a signature decline.

Objective: In a recent study, performance on a certain kind of prospective memory task (PM), labeled focal PM, was sensitive to the very early stages of Alzheimer's disease (AD; Duchek, Balota, & Cortese, 2006). This study sought to replicate and extend these findings by investigating both focal and nonfocal PM, as well as possible influences of alleles of the apolipoprotein E (ApoE) gene.

Method: Thirty-five healthy older adults and 33 adults in the very earliest stages of AD, as determined by the clinical dementia rating scale, completed both focal and nonfocal PM tasks.

The utility of placing recollection in opposition to familiarity in early discrimination of healthy aging and very mild dementia of the Alzheimer's type.

This study explored the ability to control familiarity-based information in a memory exclusion paradigm in healthy young, older adults, and early stage DAT individuals. We compared the predictive power of memory exclusion performance to standard psychometric performance in discriminating between aging and the earliest stage of DAT and between APOe4-present and APOe4-absent genotype in healthy control individuals. Participants responded "yes" to words that were previously semantically encoded, and "no" to words that were previously read aloud and to new words.

Forgetting and recovering the unforgettable.

Two experiments demonstrated striking, reversible forgetting effects that occurred even for a list of expletives. The experiments used a procedure based on the classic memory mechanisms of interference and retrieval cuing. Interference reduced recall dramatically, although appropriate cues triggered complete recovery.