Publications by authors named "S Moug"

Variation in outcomes definitions and reporting limit the utility of clinical trial results. The Core Outcome Research Measures in Anal Cancer (CORMAC) project developed a core outcome set (COS) for chemoradiotherapy trials for anal squamous cell carcinoma (ASCC) through an international healthcare professional and patient consensus process. The CORMAC-COS comprises 19 outcomes across 4 domains (disease activity, survival, toxicity, life impact).

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Background: Machine learning (ML) methods can identify complex patterns of treatment effect heterogeneity. However, before ML can help to personalize decision making, transparent approaches must be developed that draw on clinical judgment. We develop an approach that combines clinical judgment with ML to generate appropriate comparative effectiveness evidence for informing decision making.

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Article Synopsis
  • Older adults (65+) represent a significant portion of emergency laparotomy cases in the UK, yet there's limited data on patients who require surgery but do not undergo it, referred to as NoLap patients.
  • A study across 64 surgical centers tracked 750 NoLap patients over a 90-day period and found that 60% were female with a median age of 83, most suffering from frailty and severe comorbidities, leading to a high 90-day mortality rate of 79%.
  • The findings highlight the complex medical challenges faced by NoLap patients, with a small percentage surviving long-term but requiring increased care, emphasizing the need for further research on the decision-making process surrounding surgery in this high-risk group.
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Article Synopsis
  • Some surgeons are unsure about treating appendicitis without surgery because they worry about it coming back or being something more serious.
  • A study looked at 625 patients who were treated without surgery and found that 71% didn't need surgery after a year, but some still did.
  • Things like having certain risks can make it more likely for someone to need surgery later, so doctors should keep a close eye on those patients.
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Aim: Surgeon personality is a factor influencing rectal anastomotic decision-making. However, it is unclear how or why this may be the case, or what aspects of personality are involved. The aim of this study was to investigate the views of colorectal surgeons on how their individual personality may influence variation in anastomotic decision-making.

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