Development of national post-fire restoration system to assess net GHG impacts and salvage biomass availability.

In light of the recent unprecedented wildfires in Canada and the potential for increasing burned areas in the future, there is a need to explore post-fire salvage harvest and restoration and the implications for greenhouse gas (GHG) emissions. Salvage logging and replanting initiatives offer a potential solution by regrowing forests more quickly while meeting societal demands for wood and bioenergy. This study presents a comprehensive modeling framework to estimate post-fire salvage biomass and net GHG emissions relative to a 'do-nothing' baseline for all of Canada's harvest-eligible forests.

Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms.

Background: The optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A prospective multi-centre phase 2 study was performed to evaluate the efficacy and safety of everolimus and temozolomide as first-line treatment for these patients.

Methods: Patients received everolimus 10 mg daily continuously and temozolomide 150 mg/m for 7 days every 2 weeks.