Publications by authors named "S Moningi"
Background: Prostate cancer is a significant health concern in the Middle East and North Africa (MENA), with many cases diagnosed at advanced stages, a high mortality-to-incidence ratio, and low prostate cancer awareness. This study aims to evaluate prostate cancer screening practices in the region to inform effective early detection and management strategies.
Methods: A cross-sectional survey was conducted from July 1, 2023, to November 8, 2024, among physicians from 19 countries in the MENA region.
Introduction: A prostate-specific antigen (PSA) level >0.5 ng/mL after 9 to 10 weeks of neoadjuvant androgen deprivation therapy and before radiation therapy (RT) was associated with an increased PSA-failure risk; however, the impact on all-cause mortality (ACM) risk after adjusting for serum testosterone level remains unknown.
Methods: From 2005 to 2015, 350 patients with localized, unfavorable-risk prostate cancer (PC) were randomly assigned to receive androgen deprivation therapy and RT plus docetaxel vs standard of care (SOC) with androgen deprivation therapy and RT.
Article Synopsis
- Current radiation oncology (RO) trainees lack formal mentorship and training on clinical trial design and implementation, relying mostly on informal education within residency programs.
- The "Fletcher-Cox Pathway," initiated at MD Anderson Cancer Center in 2018, has successfully established a structured clinical trial training program for RO residents, receiving positive feedback and participation.
- The program enables trainees to design and submit clinical trials, fostering mentorship relationships and aiming to create a national platform to enhance access to clinical trial education and resources in RO.
Prostate cancer has substantial heterogeneity in clinical outcomes and therapeutic responses, posing challenges in predicting disease progression and tailoring treatment strategies. Recent studies have highlighted the potential prognostic value of evaluating the tumor microenvironment, including the presence of a histologically overt stromal response (HOST-response) characterized by peri-glandular stromal changes and architectural distortions. This retrospective study examined patient records from The Cancer Genome Atlas database to identify genomic alterations associated with the HOST-response in prostate cancer.
View Article and Find Full Text PDF