Publications by authors named "S Molenkamp"
The association between echogenicity and progression of Dupuytren's disease (DD): Birth of an imaging biomarker?
J Plast Reconstr Aesthet Surg
November 2023
Background: The shift of focus towards disease-controlling treatments to prevent DD progression at an early stage underlines the need for objective and reliable measurements that can monitor and predict the course of disease. Ultrasound has been studied as a potential tool for this purpose. This study examined to what extent echogenicity of early DD nodules predicts clinical progression.
View Article and Find Full Text PDFThis study aimed to determine the association between the echogenicity of Dupuytren's disease nodules and myofibroblast load, and between echogenicity and nodule hardness. Thirty-eight nodules were assessed sonographically. The echogenicity of nodules was measured objectively with Image J (grey-value) and subjectively by visual inspection (hypo-, mixed and hyper-echogenicity).
View Article and Find Full Text PDFArticle Synopsis
- This study explores the reliability of using ultrasound to measure palmar nodules in patients with early Dupuytren disease (DD), focusing on four specific dimensions: width, depth, circumference, and area.
- The results show good intraobserver reliability for most measurements, particularly for the area of the nodules, but moderate interobserver reliability, indicating variability between different observers.
- It is recommended that future assessments prioritize measuring nodule area in the sagittal plane, and a significant change in measurements (beyond specific mm thresholds) is necessary to confidently determine whether the condition is improving or worsening.
Imaging for Dupuytren disease: a systematic review of the literature.
BMC Musculoskelet Disord
May 2019
Background: As treatment of Dupuytren disease (DD) is expected to shift towards prevention of progression, the use of imaging in patients with DD becomes more important. In this systematic review an overview is given of the different methods for and applications of imaging for DD that have been described.
Methods: The MEDLINE and EMBASE databases were searched for articles reporting the use of imaging in patients with DD, published before May 17, 2018.
Background: Ultrasound might enable us to measure Dupuytren's disease activity and predict disease progression. The aim of this study was to analyze whether echogenicity of Dupuytren's nodules can be used to predict progression in terms of increase in nodule size.
Methods: Ultrasonographic assessment of a Dupuytren's nodule was performed in 91 patients participating in an existing longitudinal cohort study.