Efficacy and Safety of Chemical Venous Thromboembolism Prophylaxis in Spine Trauma Patients: A Systematic Review and Meta-analysis Comparing Anticoagulant Types.

Study Design: Systematic review and meta-analysis.

Objective: To determine whether venous thromboembolism (VTE) prophylaxis is necessary after spine trauma and to assess the efficacy and safety profiles of anticoagulation agents.

Summary Of Background Data: Venous stasis, endothelial disruption, hypercoagulability, and orthopedic injury in spine trauma predispose 12%-64% of patients to deep vein thrombosis (DVT).

Cerebral manifestations of falciparum malaria in adults: more than meets the eye.

The application of neuroimaging techniques to patients with Plasmodium falciparum infection has uncovered a wide range of brain changes not only in cerebral malaria but also in noncomatose patients. We propose several hypotheses to unify findings across the spectrum of clinical malaria in adults and highlight the urgent need to evaluate potential long-term effects of cerebral alterations on neurocognition in this understudied age group.

Catheter Ablation of Atrial Fibrillation in Patients With Psoriasis: A Multicenter Study.

Background: Psoriasis is linked to an increased risk of atrial fibrillation (AF). However, data on the electrophysiological substrate and outcomes of AF ablation in patients with psoriasis are lacking.

Methods: We conducted a retrospective, multicenter study involving 48 patients with psoriasis (median age, 66 years [56-72]; 79% male) and paroxysmal (n=25.

Use of large language models as clinical decision support tools for management pancreatic adenocarcinoma using National Comprehensive Cancer Network guidelines.

Background: Large language models may form the basis of clinical decision support tools to improve rates of guideline concordant care for pancreatic ductal adenocarcinoma. The objectives of this study were to 1) define the first-pass accuracy of 2 publicly available large language models in responding to prompts on the basis of National Comprehensive Cancer Network guidelines for pancreatic ductal adenocarcinoma, 2) describe consistency of responses within each large language models, and 3) explore differences between the 2 large language models in their accuracy and verbosity.

Methods: Clinical scenarios were developed on the basis of current National Comprehensive Cancer Network guidelines.

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.

Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B.