Publications by authors named "S Modoni"
Purpose: To evaluate the electro-clinical features in association with laboratory and instrumental correlates of neurodegeneration to detect the progression of Lafora disease (LD).
Methods: We investigated the electro-clinical longitudinal data and CSF Aβ42, p-tau and t-tauAg, amyloid, and F-FDG PET of five unrelated LD families.
Results: Three progressive electro-clinical stages were identified.
Theragnostics embraces "gnosis" and "prognosis" and concerns a treatment strategy which combines diagnostics with therapeutics. The birth of what we call today theragnostics can be traced in 1936, with the proposal of radioiodine, the first radiopharmaceutical approved in 1951 by FDA, in USA, as 131I sodium iodide. In 1957, 89Sr was also approved as first therapeutic radiotracer for skeletal metastases, followed in the subsequent years by 186Rh, 153Sm and, more recently, 223Ra, the first alpha emitter clinically utilized, allowing curative results and not only a palliative effect.
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- The study aimed to evaluate incidental lung changes in asymptomatic cancer patients using [F]FDG PET/CT during the COVID-19 pandemic in Italy, where the virus was widespread.
- Researchers analyzed data from 59 centers, comparing rates of interstitial pneumonia during various periods: during COVID (March 2020), pre-COVID (January-February 2020), and a control year (2019).
- Results indicated a significant increase in interstitial pneumonia rates during the COVID period (7.1%) compared to pre-COVID (5.35%) and control (5.15%), particularly higher in Northern Italy, emphasizing the need to monitor such findings for early COVID-19 detection and management.
Rationale: In the diagnostics of neuroendocrine tumors (NETs), scintigraphy and Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) with Indium-Octreotide occupy a prominent place.The introduction in clinical practice of Gallium-labelled somatostatin analogues (DOTA-TOC, DOTA-TATE, DOTA-NOC) for Positron Emission Tomography/Computed Tomography (PET/CT), significantly improved NETs diagnostics due to greater sensitivity and improved lesion detection in addition to better patient convenience and decreased radiation dose.
Patient Concerns: We report a case of a patient who was diagnosed with a neuroendocrine tumor of the ileocecal valve.