Immune complexome analysis reveals an autoimmune signature predictive of COVID-19 severity.

Background: The factors contributing to the development of severe coronavirus disease 2019 (COVID-19) following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain unclear. Although the presence of immune complexes (ICs), formed between antibodies and their antigens, has been linked to COVID-19 severity, their role requires further investigation, and the antigens within these ICs are yet to be characterized.

Method: Here, a C1q enzyme-liked immunosorbent assay and immune complexome analysis were used to determine IC concentrations and characterize IC antigens, respectively, in the sera of 64 unvaccinated COVID-19 patients with PCR-confirmed SARS-CoV-2 infection, enrolled at seven participating centers in 2020.

Quantification of lysosomal labile Zn and monitoring of Zn efflux using a small-molecule-protein hybrid fluorescent probe.

Lysosomal labile Zn levels have been unclear. By targeting a small-molecule fluorescent Zn probe, ZnDA-3H, to lysosomes via VAMP7-Halo, the lysosomal labile Zn concentration was determined to be 1.9 nM in HeLa cells.

Metastable body-centered cubic CoMnFe alloy films with perpendicular magnetic anisotropy for spintronics memory.

A body-centered cubic (bcc) FeCo(B) is a current standard magnetic material for perpendicular magnetic tunnel junctions (-MTJs) showing both large tunnel magnetoresistance (TMR) and high interfacial perpendicular magnetic anisotropy (PMA) when MgO is utilized as a barrier material of -MTJs. Since the -MTJ is a key device of current spintronics memory, . spin-transfer-torque magnetoresistive random access memory (STT-MRAM), it attracts attention for further advance to explore new magnetic materials showing both large PMA and TMR.

A Case of Moyamoya Disease With Spontaneous Regression of Posterior Choroidal Artery Aneurysm After Improvement in Obesity and Administration of an Antihypertensive Drug.

A 24-year-old obese female (height = 162 cm, weight = 84 kg, and BMI = 32.0) developed transient dysarthria and left hemiparesis, which was diagnosed as moyamoya disease (MMD) after imaging studies. Cerebral angiography and single photon emission computed tomography studies revealed that the above symptoms were caused by hemodynamic insufficiency in the bilateral hemispheres with right-sided predominance, and a right-sided superficial temporal artery-middle cerebral artery bypass was performed.

Contextual memory bias in emotional events: Neurobiological correlates and depression risk.

Background: Contextual memory loss of emotional events plays a critical role in depression psychopathology. Individuals with depression, clinical or subclinical, exhibit enhanced and impaired memory for emotionally negative stimuli and context in an event, respectively. This suggests that contextual encoding may fail because of attentional interference caused by concurrent negative stimuli, possibly leading to contextual memory loss as a depression risk.