Publications by authors named "S Mitsunaga"
Article Synopsis
- * The study examined 132 bats from 4 species in Yamaguchi Prefecture using PCR methods to detect various viruses.
- * Researchers identified herpesviruses, adenoviruses, astroviruses, and coronaviruses, finding 12 strains that are closely related to viruses from China and South Korea.
Article Synopsis
- - The study investigates the effectiveness of S-1, a drug used after surgery for biliary tract cancer, and its relationship with certain genes involved in the metabolism of the chemotherapy drug 5-fluorouracil (5-FU).
- - Researchers analyzed tumor samples from 183 patients and categorized them based on their DPD and TP gene levels to see how these affected recurrence-free survival (RFS) when treated with S-1.
- - Findings indicated that patients with low levels of DPD and TP genes had better RFS benefits from adjuvant S-1, highlighting the potential prognostic significance of these genes in treatment outcomes.
This study aimed to confirm urinary protein fragments in relation to the presence of pancreatic ductal adenocarcinoma (PDAC) via a C-terminal proteomics strategy using exploratory and validation cohorts. Urinary fragments were examined by iTRAQ-labelling of tryptic peptides and concentrations of C-terminal fragments were evaluated. Only the urinary CD276 fragment showed a fold change (FC) of > 1.
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- Austronesian is the second-largest language family globally, mainly found in Island Southeast Asia and Oceania, with limited understanding of its spread in Mainland Southeast Asia.
- This study analyzed genetic data from 369 individuals with mitogenomes and 170 individuals' Y-chromosomal SNPs from Vietnamese Austronesian and neighboring Austroasiatic groups to uncover population connections.
- Results showed some genetic consistency with matrilocality among certain VN-AN groups and closer genetic ties with VN-AA groups, indicating that the spread of AN speakers involved both cultural and demic diffusion.
Article Synopsis
- Chemoradiotherapy (CRT) significantly alters the immune microenvironment in esophageal squamous cell carcinoma (ESCC), enhancing the presence of certain T cells while reducing regulatory T cells and macrophages.* ! -
- A comprehensive analysis of biopsy specimens from ESCC patients pre- and post-CRT revealed that an increase in PD-1 expressing CD8 T cells is associated with better treatment responses and overall survival.* ! -
- The study suggests that the density of PD-1CD8 T cells can serve as a predictive marker for patient outcomes, highlighting the need for additional treatments like PD-1 inhibitors after CRT.* !