Publications by authors named "S Mitani"
Arthropathy is a common complication in haemophilia and decreases quality of life. It has been known that concentrations of β-hydroxybutyrate (BHB) in blood are increased by a ketogenic diet, and elevated levels of circulating BHB restricts the progression of inflammation-mediated joint pathological changes. We hypothesized that elevation of blood BHB concentrations could be effective for reducing the progression of bleeding-induced arthropathy by moderating the inflammatory responses of macrophages.
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Dedifferentiated liposarcoma (DDLPS) comprises a high-grade dedifferentiated (DD) component and a juxtaposed well-differentiated (WD) component. The DD component is believed to originate from the WD component by acquiring additional genomic alterations. In this study, we performed multiregion genome, epigenome, and transcriptome analyses of three patients with DDLPS.
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- Researchers are exploring liver sinusoidal endothelial cells (LSECs) and their progenitor cells (LPCs) from human pluripotent stem cells (PSCs) as potential treatments for hemophilia A, a condition caused by insufficient coagulation factor VIII (FVIII) production.* -
- The study aimed to enhance the process of mesoderm differentiation to efficiently produce LSEC-like cells from human induced pluripotent stem cells (iPSCs), observing a successful differentiation rate of approximately 65% for LPCs and 54% for LSEC-like cells.* -
- Optimizing specific factors like CHIR99021 and bone morphogenetic protein 4 led to significant FVIII protein secretion from L
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- In spinal surgery, accurate implant placement is vital, and intraoperative fluoroscopy is often used to avoid complications from screw misplacement.
- However, this technique exposes surgeons and staff to radiation, making it important for them to understand dosage and safety measures.
- A study created an aerial radiation dose distribution map for lateral fluoroscopy during posterior spinal fusion, revealing that primary surgeons receive the highest radiation exposure, followed by scrub nurses.