[Exocrine function of the pancreas under the effect of different doses of hexachlorocyclohexane].

Experiments conducted on albino rats poisoned with different doses of hexachlorocyclohexane (HCCH) demonstrated that large doses of this compound (1/3 DL50) following their single introduction were capable of inhibiting the secretion of the amylase, lipase, and proteases of the pancreas. Of a prolonged action of relatively small doses of HCCH (1/20 and 1/50 DL50) is characteristic an initial inhibition and subsequent stimulation of the exosecretory function of the pancreas. A definite inverse relation between the amount of the introduced HCCH dose and the duration of the pancreatic inhibition period was noted.

[Influence of tetramethylthiuramide sulfide on the exocrine function of the pancreas].

The influence of different doses of tetramethylthiuramine sulphide (TMTDS) on the activity of the amylase, lipase and proteases in the pancreatic homogenate and the small intestine contents of albino rats was studied. Six hours after a single administration of the compound in a dose of 1/3 DL50 a 2--2.5-fold drop of the enzymatic activity in the chyme was observed and 24 hours thereafter it was inhibited in the glandular tissue as well.