Role of piperacillin in surgical prophylaxis of genitourinary infections.

One hundred sixty-five men and women undergoing open or transurethral urologic surgery participated in a study designed to compare the prophylactic efficacy and safety of piperacillin with those of cefotaxime when administered perioperatively. The piperacillin-treated group received 2 Gm one hour before surgery and 2 Gm three hours later, and the cefotaxime-treated group was administered 1 Gm on the same schedule. In 9 per cent of the piperacillin-treated patients and in 11 per cent of the cefotaxime-treated patients postoperative urinary tract infections developed, although no patient in either group had sepsis.

Perioperative mezlocillin vs cefotaxime to prevent infections after genitourinary surgery.

This is a report of a randomized, comparative, double-blind study of mezlocillin and cefotaxime given perioperatively to 100 patients undergoing genitourinary surgery. Of 94 evaluable patients, 2 (4.7%) in the mezlocillin group and 2 (3.

Ceftriaxone for once-a-day therapy of urinary tract infections.

Ceftriaxone given once-a-day was compared with cefazolin given three times daily as therapy for complicated and uncomplicated urinary tract infections. One hundred ten patients were randomly assigned to receive either 1 g of ceftriaxone every 24 hours or 1 g of cefazolin every eight hours. Standard bacteriologic methods were used to identify the pathogens and their susceptibilities before treatment and at intervals during and after treatment.

Antibiotic prophylaxis for genitourinary surgery in community hospitals.

For 92 patients who had undergone transurethral and open urologic surgery a prospective, randomized, double-blind study was done that compared the effects of ceftriaxone, a third generation cephalosporin, to placebo. The 2 groups were similar in respect to demographic characteristics. Ceftriaxone reduced significantly the incidence of postoperative infection (p less than 0.

Perioperative use of ceftazidime as a prophylactic agent in transurethral surgery.

Sixty-eight patients undergoing transurethral surgery were randomly assigned to receive either a single dose of ceftazidime (31 patients) preoperatively, or three doses of cefotaxime (34 patients) perioperatively, as prophylaxis. In this study, only 1/20 male patients (5%), and none of the female patients, developed an infection. We conclude that single-dose prophylaxis, with a safe, broad-spectrum antimicrobial, provides adequate protection against postoperative infection in genitourinary surgery.