Publications by authors named "S Miliauskas"
Article Synopsis
- Pulmonary lymphangiomatosis (PL) is an extremely rare lung disease marked by abnormal lymphatic growth, with no established diagnostic or treatment guidelines, prompting a study to gather patient data.
- The study reviewed 12 patients diagnosed from 1996 to 2022, noting that most were younger women, non-smokers, and commonly experienced symptoms like difficulty breathing and coughing up blood or lymphatic fluid, with severe impacts on lung function.
- Treatment with sirolimus resulted in significant improvements for patients, although further research is needed to fully understand the disease and develop comprehensive treatment strategies.
The non-canonical PD-L1 pathway revealed that programmed-death ligand 1 (PD-L1) expression in immune cells also plays a crucial role in immune response. Moreover, immune cell distribution in a tumour microenvironment (TME) is pivotal for tumour genesis. However, the results remain controversial and further research is needed.
View Article and Find Full Text PDFBackground: A post-authorisation safety study (PASS) on delamanid (DLM) was conducted as part of a post-approval commitment to the European Medicines Agency. The aim of this study was to evaluate the use of DLM in a real-life setting, its safety, and treatment outcomes in patients with multidrug-resistant TB (MDR-TB).
Methods: This was a prospective, multicentric, non-interventional study conducted in the European Union.
Anti-interleukin (IL) 5 is an effective treatment modality for inhibiting eosinophilic inflammation in patients with T2-high severe asthma. The aim of this study was to determine the clinical efficacy and serum levels of type 2 inflammatory mediators during 24 weeks of mepolizumab treatment in patients with T2-high severe asthma. Eighteen patients with T2-high severe asthma were enrolled in this study.
View Article and Find Full Text PDF: Chronic obstructive pulmonary disease (COPD) has significant systemic manifestations, including cardiovascular morbidity. The main aim of our study was to evaluate the effect of short-term COPD treatment with tiotropium/olodaterol (TIO/OLO) 5/5 μg on cardiac function and autonomic integrity. : Twenty-nine patients with newly diagnosed moderate-to-severe COPD were enrolled.
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