Publications by authors named "S Miethe"

Article Synopsis
  • Impaired interaction between fibroblasts and AT2 pneumocytes contributes to chronic lung diseases like idiopathic pulmonary fibrosis (IPF), with Mucin 5B (MUC5B) being associated with the condition.
  • Research using an organoid model showed that fibroblasts with high fibrosis markers can alter STAT3 signaling in AT2 cells, leading to cystic growth and increased MUC5B expression, influenced by the cytokine IL-6.
  • The study also demonstrated that the drug dasatinib can block the formation of these cystic organoids, suggesting a potential avenue for drug development to address these interactions in IPF.
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Objectives: Emotion regulation plays an important role in the development and maintenance of psychopathology. However, the question whether specific ER skills are related to specific psychological symptoms has rarely been studied, but has important implications for targeted interventions. This analysis aims to explore potential differential associations between various ER skills and psychological symptoms using a network analysis approach.

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Recent studies reveal a critical role of tumor cell-released extracellular vesicles (EVs) in pancreatic cancer (PC) progression. However, driver genes that direct EV function, the EV-recipient cells, and their cellular response to EV uptake remain to be identified. Therefore, we studied the role of Bcl-2-associated-anthanogene 6 (BAG6), a regulator of EV biogenesis for cancer progression.

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Background: Empirical evidence shows that 4.6-6.3% of all women develop a post-traumatic stress disorder (PTSD) and approximately 10-15% postpartum depression (PPD) following childbirth.

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Alveolar type 2 and club cells are part of the stem cell niche of the lung and their differentiation is required for pulmonary homeostasis and tissue regeneration. A disturbed crosstalk between fibroblasts and epithelial cells contributes to the loss of lung structure in chronic lung diseases. Therefore, it is important to understand how fibroblasts and lung epithelial cells interact during regeneration.

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