Publications by authors named "S Mieko Temple"

Background: Fitness assessment of horses remains challenging. Heart rate variability (HRV) can be used to monitor human athlete's training, but its value is unknown in horses.

Hypothesis: The linear domain HRV variables are affected by fitness.

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As the field of neural organoids and assembloids rapidly expands, there is an emergent need for guidance and advice on designing, conducting and reporting experiments to increase the reproducibility and utility of these models. Here, our consortium- representing specialized laboratories from around the world- presents a framework for the experimental process that ranges from ensuring the quality and integrity of human pluripotent stem cells to characterizing and manipulating neural cells in vitro, and from transplantation techniques to considerations for modeling human development, evolution, and disease. As with all scientific endeavors, we advocate for rigorous experimental designs tailored to explicit scientific questions, and transparent methodologies and data sharing, to provide useful knowledge for both current research practices and for developing regulatory standards.

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Article Synopsis
  • Recent positive selection can lead to an accumulation of long identity-by-descent (IBD) haplotypes near specific genetic loci, which can help identify areas of adaptive evolution.
  • The proposed statistical methods aim to locate these regions, identify potential sweeping alleles, and estimate the selection coefficient (s) through innovative techniques like selection scans and parametric bootstrap for uncertainty quantification.
  • In extensive simulations, these methods outperform existing techniques, providing more accurate estimates of selection in data from European ancestry samples, demonstrating their effectiveness in studying recent adaptive evolution without needing known causal alleles or time series information.
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Many residents in Skilled Nursing Facilities (SNFs) present with dysphagia and receive altered diets or liquids to minimize the risk of complications. Limited access to timely instrumental evaluations of swallow may impede the best management of these dysphagic residents. De-identified FEES reports completed by a mobile FEES company during a single month, January 2019, were reviewed.

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