Publications by authors named "S Michowiz"
Article Synopsis
- - The study analyzed diabetic retinopathy in two mouse models: 30 mice with spontaneous type 1 diabetes and 28 chemically induced type 1 diabetes, as well as 20 mice with type 2 diabetes, comparing them to control groups.
- - The researchers assessed retinal thickness, gene expression, and vasculopathy, noting increased retinal thickness and changes in immune response markers after injecting anti-VEGF treatments.
- - The findings suggest that diabetic retinopathy in mice closely resembles that in humans, which could help in developing new treatment strategies for the disease.
Objective: To investigate pediatric low-grade gliomas for alterations in .
Materials And Methods: DNA and RNA were extracted from 62 pediatric gliomas. Molecular methods included PCR, RT-PCR, and RNA sequencing; Sanger sequencing was used for validation.
Introduction: Hydrocephalus persists in 10-40% of children with posterior fossa tumours (PFT). A delay in commencement of adjuvant therapy (AT) can negatively influence survival. The objective of this study was to determine whether postoperative cerebrospinal fluid (CSF) diversion procedures caused potentially preventable delays in AT.
View Article and Find Full Text PDFAs treatment protocols for medulloblastoma (MB) are becoming subgroup-specific, means for reliably distinguishing between its subgroups are a timely need. Currently available methods include immunohistochemical stains, which are subjective and often inconclusive, and molecular techniques-e.g.
View Article and Find Full Text PDFDifferences in RNA and microRNA Expression Between PTCH1- and SUFU-mutated Medulloblastoma.
Cancer Genomics Proteomics
December 2021
Article Synopsis
- Germline mutations in PTCH1 or SUFU lead to Gorlin's syndrome, increasing the risk of SHH-subgroup medulloblastoma, but complicating treatment due to radiotherapy limitations and inefficacy of current SHH inhibitors.
- This study analyzed RNA and microRNA expression differences between tumors from patients with PTCH1 and SUFU mutations to identify potential new treatment options.
- Findings revealed distinct expression patterns of certain miRNAs and genes in SUFU and PTCH1 tumors, suggesting different biological behaviors and potential targets for therapy in these medulloblastomas.