Publications by authors named "S Miano"
Article Synopsis
- * Researchers analyzed data from over 1500 patients and found that women reported higher sleepiness on the Epworth Sleepiness Scale compared to men, with specific age-related trends observed in different patient groups.
- * Notably, in women with narcoleptic conditions, an increase in daytime sleepiness was linked to age, while weight gain appeared later, suggesting a complex relationship that warrants further research for targeted treatment approaches.
Article Synopsis
- The study investigates the frequency of psychiatric disorders in patients with narcolepsy type-1 (NT1) and other central disorders of hypersomnolence (OCH), finding that 38 out of 90 patients (27% of NT1 and 48% of OCH) had at least one psychiatric issue.
- Major depressive episodes and suicidality were the most common psychiatric conditions observed, with a notable prevalence among females.
- Those with psychiatric comorbidities experienced more severe fatigue, apathy, disturbed sleep, and poorer overall quality of life, indicating a negative impact on their daily functioning due to the combination of these disorders and hypersomnolence symptoms.
Article Synopsis
- Narcolepsy and obstructive sleep apnea (OSA) are major causes of excessive daytime sleepiness (EDS), but differentiating between them can be challenging, especially when they occur in the same patient due to limited management guidelines.
- A literature review identified that between 24.8% and 51.4% of adults with narcolepsy type 1 (NT1) also have OSA, yet there is a lack of comprehensive studies on treating EDS in these patients.
- The link between NT1 and OSA may be due to orexin's role in regulating sleep and breathing, and more research is needed to explore effective treatments and understand orexin's function in sleep disorders related to EDS.
The manifestations of chronic insomnia undergo age-related changes. In younger infants and children, behavioral insomnia emerges as the most prevalent form and typically responds to behavioral interventions. However, distinct clusters of clinical presentations suggest the presence of various phenotypes, potentially implicating the primary involvement of specific neurotransmitters.
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- Aggressive angiomyxoma (AAM) is a rare tumor found mostly in the pelvic area of young women, known for its slow growth and tendency to invade nearby tissues without a clear boundary.
- Diagnosing AAM before surgery is challenging due to its rarity and lack of specific symptoms, making complete removal difficult during treatment.
- Despite surgical excision being the primary approach, recurrence occurs in up to 40% of cases, sometimes many years later; this paper aims to provide updated information on diagnosis and management of AAM based on recent clinical experiences.