Evidence of Heating-Dominated Urban NO Emissions.

Road transport NO emissions in many high-income countries have steadily reduced due to improved exhaust after-treatment technology. However, ambient concentrations of NO, O and PM continue to exceed World Health Organization guidelines in many cities globally. The megacity of London has taken an international lead in mobility interventions through the use of low-emission zones.

Undifferentiated Human Amniotic Fluid Progenitor Cells Promote Bone Regeneration in Vivo.

The treatment of large bone defects requires bone tissue substitutes. However, the lack of accessible autologous bone, especially in newborns with spina bifida or cleft palate conditions, severely limits therapeutic options involving bone grafts. Here, an engineering approach to reconstruct bone is presented by combining human amniocentesis-derived amniotic fluid progenitor cells (hAFCs) and a biomimetic, injectable, and fully synthetic poly(ethylene glycol) hydrogel that is crosslinked enzymatically by transglutaminase FXIII (TG-PEG).

Lateralizing value of interictal epileptiform discharges and other parameters in hypothalamic hamartoma.

Objective: Hypothalamic hamartomas (HHs) are associated with pharmacoresistant epilepsy. Stereotactic radiofrequency thermocoagulation (SRT) shows promise as a disconnecting intervention. Although magnetic resonance imaging (MRI) is typically used to determine the attachment and intervention side, it presents challenges in cases of bilaterally attached HH, where the epileptogenic side is unclear.

Implementation of patient-reported outcome dashboards within the electronic health record to support shared decision-making in serious chronic illness.

Background: Attending to patient-reported outcomes (PROs) using data visualisation dashboards could enhance shared decision-making (SDM) and care delivery for serious chronic illnesses. However, few studies have evaluated real-world strategies and resulting implementation outcomes of PRO dashboards.

Method: From June 2020 to January 2022, we implemented an electronic health record (EHR)-integrated PRO dashboard for advanced cancer and chronic kidney disease.

Conversion of pyridoxal to pyridoxamine with NH and H on nickel generates a protometabolic nitrogen shuttle under serpentinizing conditions.

Serpentinizing hydrothermal vents are likely sites for the origin of metabolism because they produce H as a source of electrons for CO reduction while depositing zero-valent iron, cobalt, and nickel as catalysts for organic reactions. Recent work has shown that solid-state nickel can catalyze the H-dependent reduction of CO to various organic acids and their reductive amination with H and NH to biological amino acids under the conditions of H-producing hydrothermal vents and that amino acid synthesis from NH, H, and 2-oxoacids is facile in the presence of Ni. Such reactions suggest a metallic origin of metabolism during early biochemical evolution because single metals replace the function of over 130 enzymatic reactions at the core of metabolism in microbes that use the acetyl-CoA pathway of CO fixation.