mmPrivPose3D: A dataset for pose estimation and gesture command recognition in human-robot collaboration using frequency modulated continuous wave 60Hhz RaDAR.

3D pose estimation and gesture command recognition are crucial for ensuring safety and improving human-robot interaction. While RGB-D cameras are commonly used for these tasks, they often raise privacy concerns due to their ability to capture detailed visual data of human operators. In contrast, using RaDAR sensors offers a privacy-preserving alternative, as they can output point-cloud data rather than images.

The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.

The Wnt receptor Ryk is an evolutionary-conserved protein important during neuronal differentiation through several mechanisms, including γ-secretase cleavage and nuclear translocation of its intracellular domain (Ryk-ICD). Although the Wnt pathway may be neuroprotective, the role of Ryk in neurodegenerative disease remains unknown. We found that Ryk is up-regulated in neurons expressing mutant huntingtin (HTT) in several models of Huntington's disease (HD).

Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.

One of the current challenges of neurodegenerative disease research is to determine whether signaling pathways that are essential to cellular homeostasis might contribute to neuronal survival and modulate the pathogenic process in human disease. In Caenorhabditis elegans, sir-2.1/SIRT1 overexpression protects neurons from the early phases of expanded polyglutamine (polyQ) toxicity, and this protection requires the longevity-promoting factor daf-16/FOXO.

Genetic diversity in an indigenous horse breed: implications for mating strategies and the control of future inbreeding.

The Franches-Montagnes is an indigenous Swiss horse breed, with approximately 2500 foalings per year. The stud book is closed, and no introgression from other horse breeds was conducted since 1998. Since 2006, breeding values for 43 different traits (conformation, performance and coat colour) are estimated with a best linear unbiased prediction (BLUP) multiple trait animal model.