Small, Fluorinated Mn Chelate as an Efficient H and F MRI Probe.

We explore the potential of fluorine-containing small Mn chelates as alternatives to perfluorinated nanoparticles, widely used as F MRI probes. In MnL1, the cyclohexanediamine skeleton and two piperidine rings, involving each a metal-coordinating amide group and an appended CF moiety, provide high rigidity to the complex. This allows for good control of the Mn-F distance (r=8.

Influence of SPION Surface Coating on Magnetic Properties and Theranostic Profile.

This study aimed to develop multifunctional nanoplatforms for both cancer imaging and therapy using superparamagnetic iron oxide nanoparticles (SPIONs). Two distinct synthetic methods, reduction-precipitation (M) and co-precipitation at controlled pH (M), were explored, including the assessment of the coating's influence, namely dextran and gold, on their magnetic properties. These SPIONs were further functionalized with gadolinium to act as dual T1/T2 contrast agents for magnetic resonance imaging (MRI).

Peptide-Conjugated MRI Probe Targeted to Netrin-1, a Novel Metastatic Breast Cancer Biomarker.

Despite significant progress in cancer imaging and treatment over the years, early diagnosis and metastasis detection remain a challenge. Molecular magnetic resonance imaging (MRI), with its high resolution, can be well adapted to fulfill this need, requiring the design of contrast agents which target specific tumor biomarkers. Netrin-1 is an extracellular protein overexpressed in metastatic breast cancer and implicated in tumor progression and the appearance of metastasis.

Zinc-sensitive MRI contrast agents: importance of local probe accumulation in zinc-rich tissues.

We present the characterisation of a Gd-based contrast agent that responds to Zn upon interaction with Human Serum Albumin. We show that the contradictory behaviour is related to Gd-accumulation in Zn-rich tissues. This highlights the importance of the biodistribution of such contrast agents.

Deciphering the Role of in the Cerebellum.

Recent studies have demonstrated a new role for , a Krüppel-like transcription factor, in skeletal muscle, specifically relating to mitochondrial function. Thus, it was of interest to analyze additional tissues that are highly reliant on optimal mitochondrial function such as the cerebellum and to decipher the role of in the functional and structural properties of this brain region. (magnetic resonance imaging and localized spectroscopy, behavior analysis) and (histology, spectroscopy analysis, enzymatic activity) techniques were applied to comprehensively assess the cerebellum of wild type (WT) and knockout (KO) mice.