Publications by authors named "S Meloche"
Hepatocellular carcinoma (HCC) is the most prevalent primary liver malignancy and is a major cause of cancer-related mortality in the world. This study aimed to characterize glutamine amino acid transporter expression profiles in HCC compared to those of normal liver cells. In vitro and in vivo models of HCC were studied using qPCR, whereas the prognostic significance of glutamine transporter expression levels within patient tumors was analyzed through RNAseq.
View Article and Find Full Text PDFHepatocellular carcinoma (HCC) is a disease of high unmet medical need that has become a global health problem. The development of targeted therapies for HCC has been hindered by the incomplete understanding of HCC pathogenesis and the limited number of relevant preclinical animal models. We recently unveiled a previously uncharacterized YES kinase (encoded by YES1)-dependent oncogenic signaling pathway in HCC.
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- ERK3/MAPK6 activates MK5, influencing cardiac fibroblast function and hypertrophy in male mice.
- Male MK5 haplo-deficient mice show reduced cardiac hypertrophy and decreased Col1a1 mRNA when faced with increased cardiac afterload.
- The study reveals that reduced ERK3 leads to lower heart mass and impacts fibroblast behavior, highlighting ERK3's crucial role in cardiac fibroblast biology.
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- Ambrosia artemisiifolia and Ambrosia trifida are significant pest species and major sources of allergens worldwide; this study presents detailed genome assemblies for both species using a hybrid approach.
- The genome assemblies reveal high completeness and substantial repetitive elements, with a notable number of genes related to herbicide resistance and allergenicity, indicating resilience against glyphosate.
- The structural evolution of A. trifida shows more genome rearrangements, while A. artemisiifolia exhibits stable genetic structures, providing insights into the evolutionary history of these allergenic plants within the Heliantheae Alliance.
Cytokinesis is the last step of cell division and is regulated by the small GTPase RhoA. RhoA activity is required for all steps of cytokinesis, including prior to abscission when daughter cells are ultimately physically separated. Like germ cells in all animals, the embryonic germline founder cell initiates cytokinesis but does not complete abscission, leaving a stable intercellular bridge between the two daughter cells.
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