Publications by authors named "S Mein"
Background: Clinical carbon ion beams offer the potential to overcome hypoxia-induced radioresistance in pancreatic tumors, due to their high dose-averaged Linear Energy Transfer (LETd), as previous studies have linked a minimum LETd within the tumor to improved local control. Current clinical practices at the Heidelberg Ion-Beam Therapy Center (HIT), which use two posterior beams, do not fully exploit the LETd advantage of carbon ions, as the high LETd is primarily focused on the beams' distal edges. Different LETd-boosting strategies, such as Spot-scanning Hadron Arc (SHArc), could enhance LETd distribution by concentrating high-LETd values in potential hypoxic tumor cores while sparing organs at risk.
View Article and Find Full Text PDFArticle Synopsis
- Spot-scanning hadron arc radiation therapy (SHArc) is a new technique for delivering ion beams that may improve the precision of radiation treatment and the distribution of energy within tumors.
- The study involved creating and testing treatment plans in a material that mimics human tissue, verifying dose delivery with tools, and assessing the impact on A549 lung cancer cells in different oxygen conditions.
- Results indicated that SHArc effectively matches planned radiation doses and appears promising for targeting tumors that are resistant to standard radiation due to low oxygen levels, while offering lower surrounding tissue radiation compared to other methods.
Background: The role of radiolytic oxygen consumption for the in-vitro "Ultra-High Dose Rate" (UHDR) sparing and in-vivo FLASH effect is subject to active debate, but data on key dependencies such as the radiation quality are lacking.
Purpose: The influence of "dose-averaged Linear Energy Transfer" (LETd) and dose rate on radiolytic oxygen consumption was investigated by monitoring the oxygen concentration during irradiation with electrons, protons, helium, carbon, and oxygen ions at UHDR and "Standard Dose Rates" (SDR).
Methods: Sealed "Bovine Serum Albumin" (BSA) 5% samples were exposed to 15 Gy of electrons and protons, and for the first time helium, carbon, and oxygen ions with LETd values of 1, 5.