Publications by authors named "S Meijer"
Background: Potentially curative therapy for locally advanced gastric cancer consists of gastrectomy, usually in combination with perioperative chemotherapy. An oncological resection includes a radical (R0) gastrectomy and modified D2 lymphadenectomy; generally, a total omentectomy is also performed, to ensure the removal of possible microscopic disease. However, the omentum functions as a regulator of regional immune responses to prevent infections and prevents adhesions which could lead to bowel obstructions.
View Article and Find Full Text PDFBackground: To enable personalized treatment and shared decision-making in chronic care, relevant health information is collected. However, health information is often fragmented across hospital information systems, digital health apps, and questionnaire portals. This also pertains to hemophilia care, in which scattered information hampers integrated care.
View Article and Find Full Text PDFArticle Synopsis
- Transcranial ultrasonic stimulation (TUS) is a non-invasive technique showing promise for neuromodulation in humans, especially affecting motor cortical functions, although it’s been primarily tested in animals so far.
- Recent studies indicated that the motor inhibition effects observed in humans may actually stem from peripheral auditory stimulation rather than direct neuromodulatory action of TUS.
- The findings urge researchers to reassess prior studies that didn't control for auditory confounds and emphasize the need for rigorous experimental designs to ensure accurate interpretations in future TUS research.
Exploring Hospital Overcrowding with an Explainable Time-to-Event Machine Learning Approach.
Stud Health Technol Inform
August 2024
Emergency department (ED) overcrowding is a complex problem that is intricately linked with the operations of other hospital departments. Leveraging ED real-world production data provides a unique opportunity to comprehend this multifaceted problem holistically. This paper introduces a novel approach to analyse healthcare production data, treating the length of stay of patients, and the follow up decision regarding discharge or admission to the hospital as a time-to-event analysis problem.
View Article and Find Full Text PDFBackground: HER2 targeting in esophageal adenocarcinoma (EAC) has shown potential, but often fails to show durable response. Given the contributions of the tumor immune microenvironment (TIME) to therapeutic responses, we aimed to chart the TIME characteristics of HER2 positive tumors.
Methods: 84 biopsies were taken from the TRAP cohort (neoadjuvant chemoradiotherapy (nCRT) according to CROSS with trastuzumab and pertuzumab; n = 40; HER2n = 40) and a control cohort with nCRT only (n = 44; HER2- n = 40, HER2n = 4) before treatment.