Publications by authors named "S Mehdy Elahi"
A substantial portion of patients infected with SARS-CoV-2 experience prolonged complications, known as Long COVID (LC). A subset of these patients exhibits the most debilitating symptoms, similar to those defined in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). We performed bulk RNA sequencing (RNAseq) on the whole blood of LC with ME/CFS, at least 12 months post-onset of the acute disease, and compared them with controls.
View Article and Find Full Text PDFIntratumoral delivery and localized chemotherapy have demonstrated promise in tumor treatment; however, the rapid drainage of therapeutic agents from well-vascularized tumors limits their ability to achieve maximum therapeutic efficacy. Therefore, innovative approaches are needed to enhance treatment efficacy in such tumors. This study utilizes a mathematical modeling platform to assess the efficacy of combination therapy using anti-angiogenic drugs and drug-loaded nanoparticles.
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- * The analysis revealed a cut-off value for Gal-9 and ARTN that can effectively differentiate LC patients from recovered individuals and healthy controls, indicating their usefulness in screening.
- * Elevated Gal-9 levels were linked to higher inflammatory markers and cognitive impairments in LC patients, suggesting a significant role for Gal-9 in the underlying mechanisms of Long COVID and its impact on cognitive function.
Article Synopsis
- - The study investigates how cellular interactions, driven by force, contribute to cancer cell invasion, particularly in the context of cerebral cavernous malformations (CCM), which are characterized by abnormal blood vessels.
- - Researchers used an in-vitro model to demonstrate that endothelial cells lacking the CCM2 protein help recruit normal (wild-type) endothelial cells through mechanical forces and changes in the surrounding extracellular matrix, facilitating lesion growth.
- - The findings reveal that CCM2 mutant cells manipulate neighboring wild-type cells into proliferating and altering their functions, providing new insights into the mechanisms behind vascular abnormalities and tools for studying cell behavior in disease contexts.