Publications by authors named "S Meek"
Article Synopsis
- The exocyst is a key protein complex that helps with the process of exocytosis by linking secretory vesicles to the plasma membrane and coordinating various proteins involved in cell trafficking.
- Despite known structural details, its complex and adaptable roles make understanding its full function challenging.
- The review discusses current and potential future experimental methods to study the exocyst, ranging from isolated lab experiments to real-time imaging in living cells, to better understand its dynamics and functions in a natural context.
Article Synopsis
- A 33-year-old woman was found unresponsive after taking what she believed were Valium pills, but tests revealed she had ingested sulfonylureas, leading to severe hypoglycemia.
- Her blood glucose levels were critically low (15-18 mg/dL), and treatment required intravenous dextrose to stabilize her condition.
- The case highlights the potential for sulfonylureas to cause hypoglycemia and the importance of recognizing drug substitution or contamination in patients suspected of using illicit drugs.
Objectives: The aim of this study was to compare outcomes of using intravenous insulin infusion (IVII) therapy for managing hyperglycemia in a non-intensive care unit (ICU) versus an ICU setting.
Methods: We conducted a retrospective analysis on patients who received IVII for hyperglycemia. The analysis compared variables associated with hypoglycemic events while on IVII, and point-of-care blood glucose control and insulin regimens at discharge.
Article Synopsis
- The p75NTR neurotrophin receptor plays both helpful and harmful roles in nerve cell survival, but studying its effects has been complicated by the presence of different forms in mouse models.* -
- Researchers created a mutant rat that completely lacks the p75NTR protein using advanced genetic techniques, allowing for a clearer understanding of its function.* -
- These p75NTR-deficient rats are healthy and show no major brain structure changes, indicating that p75NTR is not essential for normal growth, but they offer a valuable model for exploring p75NTR's role in injury and repair processes.*
Article Synopsis
- Recent evidence challenges the previous belief that MeCP2 contributes to heterochromatin formation through liquid-liquid phase separation.
- Studies show that MeCP2 localization occurs independently of heterochromatin organization, as MeCP2 foci remain intact even when heterochromatin is disrupted.
- The research also indicates that animal models, especially mice, are not typical, as most mammals, including humans, show a diffuse distribution of MeCP2, which is influenced mainly by global DNA methylation rather than the formation of condensates.