Publications by authors named "S Medjkane"
Abscission is the final stage of cytokinesis, which cleaves the intercellular bridge (ICB) connecting two daughter cells. Abscission requires tight control of the recruitment and polymerization of the Endosomal Protein Complex Required for Transport-III (ESCRT-III) components. We explore the role of post-translational modifications in regulating ESCRT dynamics.
View Article and Find Full Text PDFArticle Synopsis
- Some germs called Theileria parasites can live inside cow's white blood cells and make them sick.
- They have special tricks to survive inside these cells, like stealing proteins from the cows so they won’t be thrown out.
- Scientists found a new medicine that helps the cows' cells fight back by making them clear out the parasites more effectively.
Article Synopsis
- Theileria parasites are causing serious diseases in cattle, leading to significant economic losses in Africa and Asia, primarily through the transformation of host cells into aggressive, immortal cells.
- The drug Buparvaquone is facing issues with resistance, prompting the need for new treatments; researchers found that Trifloxystrobin is effective in killing Theileria-infected lymphocytes and macrophages.
- Trifloxystrobin not only works as well as Buparvaquone in controlling the parasite but is also effective against drug-resistant strains, making it a promising candidate for future drug development against Theileria infections.
Mechanical cues from the cellular microenvironment are converted into biochemical signals controlling diverse cell behaviours, including growth and differentiation. But it is still unclear how mechanotransduction ultimately affects nuclear readouts, genome function and transcriptional programs. Key signaling pathways and transcription factors can be activated, and can relocalize to the nucleus, upon mechanosensing.
View Article and Find Full Text PDF