Publications by authors named "S Mebarek"
Menopause exacerbates osteoporosis and increases the risk of atherosclerotic plaque rupture, leading to cardiovascular mortality. Osteoporotic women are increasingly treated with teriparatide (TPTD, 1-34 parathyroid hormone), one of the few treatments that stimulate bone formation. Despite the fact that atherosclerotic plaque calcification is a hallmark of plaque development, the impact of TPTD administration on plaque calcification remain unclear.
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- The study aimed to create engineered cartilage using pyrocarbon (PyC) biomaterial and differentiated chondrocytes, focusing on a scaffold-free and mechanically stimulated process.
- By applying uniaxial cyclic compression in a specially designed tribo-bioreactor, the researchers aimed to keep the chondrocytes in a cartilage-like phenotype while enhancing the matrix composition.
- Findings indicated that the combination of PyC and dynamic stimulation led to denser constructs with improved mechanical properties and no signs of unwanted cell maturation, highlighting the effectiveness of integrating biomaterials with mechanical stimuli in tissue engineering.
Objective: This study investigates the effects of a Brazil nut-enriched diet on body composition and bone parameters in CKD animal model.
Methods: Male Wistar rats were assigned to the following groups: Sham (n=8), Nx (n=6), nephrectomized rats, and NxBN (n=6), nephrectomized rats and an enricheddiet with 5% Brazil nut. Body composition parameters were obtained by dual-energy X- ray absorptiometry (DXA).
Article Synopsis
- Scientists found a special mix of tiny molecules called microRNAs that can help understand and fix damage caused by radiation in space.
- They did experiments to see how a treatment using three different microRNAs could help protect cells from this damage by reducing inflammation and improving cell functions.
- The results from astronauts in different space missions showed that this treatment might help astronauts stay healthier during long space trips.
Mineralization-competent cells, including hypertrophic chondrocytes, mature osteoblasts, and osteogenic-differentiated smooth muscle cells secrete media extracellular vesicles (media vesicles) and extracellular vesicles bound to the extracellular matrix (matrix vesicles). Media vesicles are purified directly from the extracellular medium. On the other hand, matrix vesicles are purified after discarding the extracellular medium and subjecting the cells embedded in the extracellular matrix or bone or cartilage tissues to an enzymatic treatment.
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