Publications by authors named "S McGinnis"
Background: Posterior Cortical Atrophy (PCA) is a clinical syndrome characterized by progressive visuospatial and visuoperceptual impairment. As the neurodegenerative disease progresses, patients lose independent functioning due to the worsening of initial symptoms and development of symptoms in other cognitive domains. The timeline of clinical progression is variable across patients, and the field currently lacks robust methods for prognostication.
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- Posterior Cortical Atrophy (PCA) is a syndrome that causes gradual problems with visual processing and spatial awareness, leading to decreased independence as symptoms worsen over time; predicting the disease's progression can be challenging due to individual variability.!* -
- The study involved recruiting PCA patients from a specialized program and using MRI scans to measure cortical thickness, which was then correlated with clinical assessments of cognitive decline over time, focusing on the CDR Sum-of-Boxes score.!* -
- Analysis of data from 34 PCA patients revealed significant cortical atrophy in posterior brain regions, especially in areas responsible for visual processing, indicating that baseline cortical atrophy can be a useful predictor of future cognitive decline in PCA patients.!*
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- Research aims to identify how tau PET imaging correlates with clinical decline in atypical Alzheimer's disease (AD) to improve patient care.
- Despite known tau accumulation in atypical AD, its predictive value for clinical decline is still uncertain.
- Findings show tau levels in the default mode network are strong predictors of decline, outperforming other clinical and imaging factors in patients with atypical AD.
Article Synopsis
- Behavioral variant frontotemporal dementia (bvFTD) is characterized by a range of neuropsychiatric symptoms (NPS) that occur frequently both early and late in the illness, impacting emotional and behavioral aspects.
- A study involving 354 participants identified four main clusters of NPS—affective, disinhibited, compulsive, and psychosis—showing that some symptoms fluctuate while others remain stable over time.
- The findings suggest that NPS could be linked to specific brain network disruptions, providing insight for potential treatments, although the variability in symptoms indicates they may not be reliable indicators of disease progression.
The purpose of this study was to evaluate the performance of HF183 Bacteroides for estimating pathogen exposures during recreational water activities. We compared the use of Bacteroides-based exposure assessment to exposure assessment that relied on pathogen measurements. We considered two types of recreational water sites: those impacted by combined sewer overflows (CSOs) and those not impacted by CSOs.
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