Publications by authors named "S McDougal"
Objective: To provide updates on the epidemiology and recommendations for management of candidemia in patients with critical illness.
Data Sources: A literature search using the PubMed database (inception to March 2023) was conducted using the search terms "invasive candidiasis," "candidemia," "critically ill," "azoles," "echinocandin," "antifungal agents," "rapid diagnostics," "antifungal susceptibility testing," "therapeutic drug monitoring," "antifungal dosing," "persistent candidemia," and "Candida biofilm."
Study Selection/data Extraction: Clinical data were limited to those published in the English language.
Objective: To compare the efficacy of antimicrobial therapies used in the management of persistent methicillin-susceptible (MSSA) bacteremia.
Data Sources: A literature search using the PubMed database (inception to December 2022) was conducted using the search terms " bacteremia," "methicillin-susceptible bacteremia," "persistent methicillin-susceptible bacteremia," and "refractory methicillin-susceptible bacteremia ." In addition, therapeutic agents which could be used as treatment for MSSA including "nafcillin," "oxacillin," "cefazolin," "ceftaroline," "gentamicin," "rifampin," and "daptomycin" were also combined with the aforementioned search terms to capture data using these agents.
Background: Incomplete HIV seroconversion and seroreversion are increasingly documented by testing and pre-exposure prophylaxis programs more than previously recognized. This analysis reports on incomplete seroconversion and seroreversion by specimen and test type among Project DETECT participants.
Methods: Project DETECT included a longitudinal study of point-of-care tests.
Background: HIV testing guidelines provided by the Centers for Disease Control and Prevention (CDC) are continually changing to reflect advancements in new testing technology. Evaluation of existing and new point-of-care (POC) HIV tests is crucial to inform testing guidelines and provide information to clinicians and other HIV test providers. Characterizing the performance of POC HIV tests using unprocessed specimens can provide estimates for the window period of detection, or the time from HIV acquisition to test positivity, which allows clinicians and other HIV providers to select the appropriate POC HIV tests for persons who may be recently infected with HIV.
View Article and Find Full Text PDFArticle Synopsis
- The study evaluated the sensitivity and specificity of four point-of-care (POC) HIV tests using whole blood and two using oral fluid among participants from health clinics in Seattle between 2015 and 2017.
- It involved testing 1,256 visits, of which 179 were from individuals with HIV, and highlighted that sensitivity was slightly lower for oral fluid tests compared to whole blood tests among those on antiretroviral therapy (ART).
- Overall, the POC tests showed high sensitivity and specificity, confirming their effectiveness in identifying HIV infections, but it was recommended that clients with recent risk retest to ensure accuracy.