Non-invasive Imaging of Antisense Oligonucleotides in the Brain via In Vivo Click Chemistry.

Purpose: The treatment of complex neurological diseases often requires the administration of large therapeutic drugs, such as antisense oligonucleotide (ASO), by lumbar puncture into the intrathecal space in order to bypass the blood-brain barrier. Despite the growing number of ASOs in clinical development, there are still uncertainties regarding their dosing, primarily around their distribution and kinetics in the brain following intrathecal injection. The challenge of taking measurements within the delicate structures of the central nervous system (CNS) necessitates the use of non-invasive nuclear imaging, such as positron emission tomography (PET).

Instantaneous Best Integer Equivariant Position Estimation Using Google Pixel 4 Smartphones for Single- and Dual-Frequency, Multi-GNSS Short-Baseline RTK.

High-precision global navigation satellite system (GNSS) positioning and navigation can be achieved with carrier-phase ambiguity resolution when the integer least squares (ILS) success rate (SR) is high. The users typically prefer the float solution under the scenario of having a low SR, and the ILS solution when the SR is high. The best integer equivariant (BIE) estimator is an alternative solution since it minimizes the mean squared errors (MSEs); hence, it will always be superior to both its float and ILS counterparts.

Stability of Droperidol 0.625 mg/mL Diluted with 0.9% Sodium Chloride Injection and Stored in Polypropylene Syringes.

The purpose of this study was to determine the stability of droperidol 0.625 mg/mL in 0.9% sodium chloride solution that was packaged in polypropylene syringes and stored at controlled ambient conditions.

Rescuer position for tracheal intubation on the ground.

Background: Emergency oral tracheal intubations in the pre-hospital setting can be more difficult because the rescuer's position with respect to a patient lying on the ground may not provide optimal conditions for intubation. Since optimal visualisation of the larynx often depends on the force generated during laryngoscopy, we measured the pressure required for intubation (P(i)) as well as the maximum pressure (P(max)) that can be generated with the laryngoscopy blade in seven intubator positions.

Methods: Nineteen hospital personnel with intubation experience participated in this study.

Coseismic and Postseismic Fault Slip for the 17 August 1999, M = 7.5, Izmit, Turkey Earthquake.

We use Global Positioning System (GPS) observations and elastic half-space models to estimate the distribution of coseismic and postseismic slip along the Izmit earthquake rupture. Our results indicate that large coseismic slip (reaching 5.7 meters) is confined to the upper 10 kilometers of the crust, correlates with structurally distinct fault segments, and is relatively low near the hypocenter.