Publications by authors named "S Mazzaferro"
Article Synopsis
- Vertebral fractures (VFs) are the most common type of osteoporotic fractures and significantly affect patients by increasing mortality rates, reducing quality of life, and elevating the risk of future fractures, particularly in those with chronic kidney disease (CKD).
- VFs are often underdiagnosed in CKD patients, and their risk factors not only include typical ones like age and bone density but also CKD-specific factors such as the severity of kidney dysfunction and treatment history.
- Recent changes in clinical guidelines emphasize the need for better diagnosis and treatment strategies for VFs in CKD patients, urging a proactive approach to address this overlooked health issue.
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a hereditary kidney disorder that may progress to kidney failure, accounting for 5-10% of all patients with end-stage kidney disease (ESKD). Clinical data, as well as molecular genetics and advanced imaging techniques have provided surrogate prognostic biomarkers to predict rapid decline in kidney function, nonetheless enhanced tools for assessing prognosis for ADPKD are still needed. The aim of this study was to analyze specific microRNAs involved in the pathogenesis of ADPKD and in the development of renal fibrosis, evaluating their potential role as predictors of renal function loss.
View Article and Find Full Text PDFIntroduction: Secondary hyperparathyroidism (SHPT) increases the risk of fractures and cardiovascular (CV) disease in patients on hemodialysis (HD). The relationship between parathyroid hormone (PTH) and outcomes has been inconsistent, possibly due to variable bone responsiveness to PTH. The KDIGO guideline suggests monitoring total alkaline phosphatase (ALP), but the role of ALP versus PTH in the management of mineral and bone disorder (MBD) is not clear.
View Article and Find Full Text PDFItalian Guidelines for the Management of Sporadic Primary Hyperparathyroidism.
Endocr Metab Immune Disord Drug Targets
June 2024
Article Synopsis
- The guideline is designed to help healthcare professionals manage sporadic primary hyperparathyroidism (PHPT) in adults, excluding cases during pregnancy.
- Developed through a systematic review process, the guideline focuses on identifying critical outcomes that impact treatment decisions, emphasizing pharmacological and surgical options.
- Key recommendations include recommending parathyroidectomy for symptomatic patients or those with specific criteria, while also providing guidance for monitoring other related health issues.
Background: In Italy, nephrology residency is available in twenty-one nephrology schools, each with its own strengths and weaknesses. The present study is aimed at exploring the residents' satisfaction with their training programs.
Methods: Between April 20th and May 19th, 2021, a questionnaire on residency satisfaction consisting of 49 items was sent to 586 residents and 175 recently certified specialists (qualified to practice as nephrologists in 2019 and 2020), with a response rate of 81% and 51%, respectively.