Rapid change in red cell blood group systems after the main Out of Africa of Homo sapiens.

Despite the advances in paleogenomics, red cell blood group systems in ancient human populations remain scarcely known. Pioneer attempts showed that Neandertal and Denisova, two archaic hominid populations inhabiting Eurasia, expressed blood groups currently found in sub-Saharans and a rare "rhesus", part of which is found in Oceanians. Herein we fully pictured the blood group genetic diversity of 22 Homo sapiens and 14 Neandertals from Eurasia living between 120,000 and 20,000 years before present (yBP).

Chain Transfer Kinetics of Rhodixan A1 RAFT/MADIX Agent.

Rhodixan A1 is the trade name for -ethyl -(1-methoxycarbonylethyl)dithiocarbonate, a RAFT/MADIX agent used by Syensqo to produce block copolymer additives for aqueous formulations on an industrial scale. Chain transfer coefficients to Rhodixan A1 determined for 25 different styrenic, acrylate, and acrylamide monomers were relatively low (0.6 < C < 3.

2-Cyanopropan-2-yl versus 1-Cyanocyclohex-1-yl Leaving Group: Comparing Reactivities of Symmetrical Trithiocarbonates in RAFT Polymerization.

This study introduces bis(1-cyanocyclohex-1-yl)trithiocarbonate (TTC-bCCH) as a novel trithiocarbonate chain transfer agent and compares its reactivity with the previously described bis(2-cyanopropan-2-yl)trithiocarbonate (TTC-bCP) for the reversible addition-fragmentation chain transfer (RAFT) polymerization of styrene (St), n-butyl acrylate (nBA), and methyl methacrylate (MMA). Significant findings include the effective control of M and low dispersities from the onset of polymerization of St and nBA showing swift addition-fragmentation kinetics, leading to similar behaviors between the two RAFT agents. In contrast, a fourfold decrease of the chain transfer constant to MMA is established for TTC-bCCH over TTC-bCP.

Synthesis, Characterizations, and Quantum Chemical Investigations on Imidazo[1,2-]pyrimidine-Schiff Base Derivative: ()-2-Phenyl--(thiophen-2-ylmethylene)imidazo[1,2-]pyrimidin-3-amine.

In this study, ()-2-phenyl--(thiophen-2-ylmethylene)imidazo[1,2-]pyrimidin-3-amine is synthesized, and detailed spectral characterizations using H NMR, C NMR, mass, and Fourier transform infrared (FT-IR) spectroscopy were performed. The optimized geometry was computed using the density functional theory method at the B3LYP/6-311++G(d,p) basis set. The theoretical FT-IR and NMR (H and C) analysis are agreed to validate the structural assignment made for .

Design, synthesis, and computational studies of novel imidazo[1,2-]pyrimidine derivatives as potential dual inhibitors of hACE2 and spike protein for blocking SARS-CoV-2 cell entry.

In the present work, a new series of imidazo[1,2-]pyrimidine Schiff base derivatives have been obtained using an easy and conventional synthetic route. The synthesized compounds were spectroscopically characterized using H, C NMR, LC-MS(ESI), and FT-IR techniques. Green metric calculations indicate adherence to several green chemistry principles.