Publications by authors named "S Mathia"
Article Synopsis
- The KDM1A histone demethylase is linked to poor prognosis in aggressive neuroblastomas due to its role in regulating cell growth and differentiation.
- Research demonstrated that NCL-1, a small molecule inhibitor of KDM1A, effectively reduced cell proliferation and induced neuronal differentiation in various neuroblastoma models.
- In vivo studies showed that NCL-1 treatment significantly decreased tumor growth in mouse models by altering tumor cell behavior and disrupting blood vessel formation.
Article Synopsis
- The study explores the role of 2,3-bisphosphoglycerate mutase (BPGM) in the kidney, highlighting its upregulation during acute kidney injury in both mice and humans.
- Using a specialized mouse model, researchers found that BPGM is mainly located in the distal nephron and its knockout led to rapid kidney injury and structural damage after just four days.
- The absence of BPGM disrupts crucial metabolic processes, elevating oxidative stress and inflammation while linking stress responses between different parts of the nephron, underscoring its importance in kidney function.
Article Synopsis
- Chronic Cyclosporine-A treatment can lead to severe side effects like kidney toxicity and anemia, potentially due to hypoxia.
- The study explored the effects of daprodustat, a hypoxia-inducible factor activator, on kidney toxicity caused by Cyclosporine-A, revealing that daprodustat significantly countered Cyclosporine-A's changes to protein expression and phosphorylation.
- While daprodustat alone had a minimal effect, its combination with Cyclosporine-A notably influenced angiogenesis-related pathways and prevented harmful impacts on blood hemoglobin levels and kidney microcirculation.
Unilateral ischemia-reperfusion (UIR) injury leads to progressive renal atrophy and tubulointerstitial fibrosis (TIF) and is commonly used to investigate the pathogenesis of the acute kidney injury-chronic kidney disease transition. Although it is well known that contralateral nephrectomy (CNX), even 2 wk post-UIR injury, can improve recovery, the physiological mechanisms and tubular signaling pathways mediating such improved recovery remain poorly defined. Here, we examined the renal hemodynamic and tubular signaling pathways associated with UIR injury and its reversal by CNX.
View Article and Find Full Text PDFBackground/aims: Recently, we have demonstrated that episodic hypoxia occurs in kidneys of mice challenged repetitively with the immunosuppressant cyclosporine A (CsA), in analogy to humans on CsA treatment. However, the molecular consequences of episodic hypoxia remain poorly defined, as is its impact on cell survival. Here, we systematically study cell response to episodic, as compared to single course hypoxia.
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