Waldenström macroglobulinemia: a review of pathogenesis, current treatment, and future prospects.

Waldenström macroglobulinemia (WM) is a chronic B-cell lymphoproliferative disorder characterized by lymphoplasmacytic cell overgrowth in the bone marrow and increased secretion of IgM immunoglobulins into the serum. Patients with WM have a variety of clinical outcomes, including long-term survival but inevitable recurrence. Recent advances in disease knowledge, including molecular and genetic principles with the discovery of MYD88 and CXCR4 mutations, have rapidly increased patient-tolerable treatment options.

Validation of radiographic visibility of root pulp in mandibular first, second and third molars in the prediction of 21 years in a sample of south Indian population: A digital panoramic radiographic study.

This study examines the radiographic visibility of root pulp (RPV) in lower first, second and third molars to validate the completion of 21 years. RPV in all lower three molars of both sides was assessed using a sample of 930 orthopantomograms of individuals aged between 15 and 30. The scoring of RPV was done using the Olze et al.

Fanconi anaemia.

A case of Fanconi anaemia in a 7-year-old male child is reported. He was grossly anaemic with typical cutaneous pigmentary changes. Peripheral smear revealed normocytic hypochromic anaemia, leukopenia and thrombocytopenia.

Nicolau syndrome.

A case of Nicolau syndrome in a woman following intramuscular injection of diclofenac sodium is reported.