The Role of Nt-Pro-Bnp in Predicting Outcome in Pediatric Hypertrophic Cardiomyopathy.

Hypothesis: The aim of the study was to evaluate the correlation between NTproBNP and left ventricular mass (LVM) in children affected by hypertrophic cardiomyopathy (HCM), both asymptomatic, symptomatic, and with implantable cardioverter-defibrillator (ICD).

Methods: A total of 225 pediatric patients were evaluated and 45 were enrolled in the study because met inclusion criteria (age < 18 years; diagnosis of hypertrophic cardiomyopathy; NTproBNP > 600 pg/ml).

Results: The analysis showed a significant correlation between NTproBNP level and LVM (p = 0.

Switch From Twice-daily Tacrolimus to Once-daily, Prolonged-release Tacrolimus in Kidney Transplantation: Long-term Outcome.

Background: One daily dose of tacrolimus (QDT) improves adherence in kidney transplant (KT) recipients. A switch from twice-daily tacrolimus (BDT) to QDT showed similar efficacy and safety.

Methods: The aim of our study was to demonstrate the long-term efficacy and safety of switching from BDT to QDT in KT recipients.

Sulfamethazine, sulfothiazole and albendazole residue dosage in food products determined by liquid chromatography/tandem mass spectrometry.

There is a growing demand for analytical techniques for the detection of a wide variety of residues from synthetic molecules in matrices such as soil, water, air and food. These techniques have to meet the requirements of speed and sensitivity as well as the ability to handle any matrix with minimal sample clean-up. Features of mass spectrometry combined with liquid chromatography can fulfill these requirements as is shown by this work which reports the use of ion spray ionization coupled with tandem mass spectrometry for the detection of some drug residues.

An in vitro investigation of the reductive metabolism of chloroform.

In hypoxic (1% pO2) and anoxic (0% pO2) incubations of CHCl3 with rat liver microsomes from PB-induced animals, no evidence of formation of monochloromethyl carbene could be found. Dichloromethane was detected as a volatile metabolite of CHCl3 in incubations with rat liver microsomes from PB-induced animals, under different oxygenation conditions (from 0% to 20% pO2). With uninduced microsomes, significant levels of dichloromethane were formed only in hypoxic (1% pO2) or anoxic incubations.