Expandable konjac fiber modulates appetite and chyme digestion in vivo by stomach-intestine-brain axis.

Appetite regulation is a lifestyle intervention strategy to maintain health. The regulatory effects of dietary fiber (especially insoluble dietary fiber), as a crucial element of the nutritional composition, on appetite remain poorly understood. This study investigated modulatory effects of konjac fiber (KF, with high and low expansion) and konjac powder (KP) on chyme digestion, gastrointestinal hormones, intestinal microbiota, appetite genes in hypothalamus, GLP-1 receptor (GLP-1R) protein in various tissues of rats by dietary intervention.

A chemical-recovery-free ammonium sulfite-based alkali pretreatment of corn stover for low-cost sugar production via fertilizer use of waste liquor.

The production of cellulosic sugars is a pivotal strategy for advancing biomass bioconversion. This study evaluated the pretreatment of corn stover using ammonium sulfite and potassium hydroxide to develop comprehensive data on sugar, lignin, chemicals, and overall mass recovery profiles in a batch reactor at 80 °C. The results indicated significant improvements in delignification, deacetylation, enzymatic digestibility, and overall sugar yield.

Mechanism of Nitrogen Conversion and Microbial Communities Controlling the Acidification and Storage of Pig Farm Fecal Water.

The effect of acidifiers on nitrogen transformation during manure wastewater storage remains unclear. In this study, we investigate the effects of two types of acidifiers on nitrogen transformation, bacterial structure, and functional genes during manure wastewater storage. The results indicate that the internal reactions in manure wastewater storage could be divided into three stages, i.

Chitooligosaccharide enhances plant resistance to P. nicotianae via sugar homeostasis and microorganism assembly.

Phytophthora nicotianae is a highly destructive soil-borne plant pathogen that leads to significant economic losses in agriculture. Chitooligosaccharides (COS) are popular biostimulant which can promote plant growth and responses to biotic and abiotic stresses. However, the role of COS in resisting the black-shank disease (BSD, caused by P.

Genetic and epigenetic mechanisms of GPRC5D loss after anti-GPRC5D CAR T-cell therapy in multiple myeloma.

G protein-coupled receptor, class C, group 5, member D (GPRC5D) has emerged as a novel target for chimeric antigen receptor (CAR) T-cell therapy, demonstrating promising efficacy in multiple myeloma (MM). However, disease relapse is still common, and the mechanism of resistance remains poorly understood. In this study, we conducted whole-genome sequencing (WGS) and whole-genome bisulfite sequencing (WGBS) on MM samples from 10 patients who relapsed after GPRC5D CAR T-cell therapy.