Publications by authors named "S Martens"
Objectives: Re-operations due to material degeneration carry a burden for patients with congenital heart disease (CHD). The study aim was to compare rapid vs. slow degeneration of biomaterials in CHD patients.
View Article and Find Full Text PDFBackground: Mass-forming intrahepatic cholangiocarcinoma (MF-ICC) is the second most common primary liver cancer and liver resection offers the best chance of possible cure. This study aimed to assess treatment outcomes and prognostic factors for long-term survival in patients who underwent curative-intent liver resection.
Methods: A retrospective analysis was conducted on prospectively collected data from patients with MF-ICC managed at the Royal North Shore/North Shore Private Hospital from January 1998 to October 2023.
Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy, the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo material is collected in larger condensates prior to its sequestration by autophagosomes. In this process, the autophagic cargo receptors SQSTM1/p62 and NBR1 drive cargo condensation, while TAX1BP1, which binds to NBR1, recruits the autophagy machinery to facilitate autophagosome biogenesis at the condensates.
View Article and Find Full Text PDFArticle Synopsis
- This study reviews surgical outcomes of pulmonary valve replacements in adults with congenital heart disease, specifically focusing on patients who underwent this procedure over the past decade.
- A total of 79 patients were analyzed, with the majority having Tetralogy of Fallot, and the surgery involved removing the old valve and using a larger bioprosthesis, often alongside other surgeries like tricuspid valve repairs.
- Results showed effective post-operative outcomes, with no severe valve insufficiency noted and improved heart function metrics in MRI studies, confirming sPVR as a safe and effective treatment option with a low mortality rate (5.1%).