Publications by authors named "S Marsigliante"
This study examined the response to cisplatin in BxPC-3, Mia-Paca-2, PANC-1, and YAPC pancreatic cancer lines with different genotypic and phenotypic characteristics, and the mechanisms associated with their resistance. BxPC-3 and MIA-PaCa-2 cell lines were the most sensitive to cisplatin, while YAPC and PANC-1 were more resistant. Consistently, in cisplatin-treated BxPC-3 cells, the cleavage patterns of pro-caspase-9, -7, -3, and PARP-1 demonstrated that they were more sensitive than YAPC cells.
View Article and Find Full Text PDFBackground/objectives: Physical inactivity in children can lead to decreased physical fitness and reduced enjoyment of physical activity. This study aimed to evaluate the impact of exergaming on physical fitness, body composition and perceived enjoyment in elementary school children.
Methods: Sixty-four male students (mean age 9.
Background: Branched-chain amino acids (BCAAs) are widely studied for their effects on muscle recovery and performance.
Aims: This study examined the effects of BCAA supplementation on anthropometric data, physical performance, delayed onset muscle soreness (DOMS), and fatigue in recreational weightlifters.
Methods: The trial involved 100 participants (50 men and 50 women), randomized into BCAA and placebo groups.
Neuroendocrine neoplasms (NENs) are a diverse group of malignancies with a shared phenotype but varying prognosis and response to current treatments. Based on their morphological features and rate of proliferation, NENs can be classified into two main groups with a distinct clinical behavior and response to treatment: (i) well-differentiated neuroendocrine tumors (NETs) or carcinoids (with a low proliferation rate), and (ii) poorly differentiated small- or large-cell neuroendocrine carcinomas (NECs) (with a high proliferation rate). For certain NENs (such as pancreatic tumors, higher-grade tumors, and those with DNA damage repair defects), chemotherapy is the main therapeutic approach.
View Article and Find Full Text PDFArticle Synopsis
- An increasing number of PhD students are feeling like frauds, which harms their mental health and journey in school.
- The study looked at 562 students and 152 supervisors in Tunisia to see how feelings of impostor syndrome relate to the empathy of the supervisors.
- It was found that more empathy from supervisors can help reduce feelings of impostor syndrome in students, highlighting the need for better support for PhD students.