Publications by authors named "S Markus"
Dynein-1 is a microtubule motor responsible for the transport of cytoplasmic cargoes. Activation of motility requires it first overcome an autoinhibited state prior to its assembly with dynactin and a cargo adaptor. Studies suggest that Lis1 may relieve dynein's autoinhibited state.
View Article and Find Full Text PDFObjective: The establishment of clinical registries is essential for the comprehensive evaluation of surgical outcomes. In 2006, the Schulthess Shoulder Arthroplasty Registry (SAR) was launched to systematically assess safety, implant longevity, functional outcomes, pain levels, quality of life, and patient satisfaction in individuals undergoing shoulder arthroplasty. This paper aims to outline the registry data and demonstrate how it is leveraged to improve clinical outcomes.
View Article and Find Full Text PDFMicrotubule-targeting agents (MTAs) have been successfully translated from basic research into clinical therapies and have been widely used as first- and second-line chemotherapy drugs for various cancers. However, current MTAs exhibit positive responses only in subsets of patients and are often accompanied by side effects due to their impact on normal cells. This underscores an urgent need to develop novel therapeutic strategies that enhance MTA efficacy while minimizing toxicity to normal tissues.
View Article and Find Full Text PDFArticle Synopsis
- Microtubule motor cytoplasmic dynein requires a specific complex assembly involving dynein, dynactin, and adapter proteins for effective transport within cells.
- Initial assumptions about the interaction between dynein and dynactin have been challenged by new cryo-EM structures that did not confirm earlier findings, suggesting a more complex relationship.
- The study identifies the N-terminus of the dynein intermediate chain as a crucial site for binding both dynactin and Ndel1, indicating the importance of a sequential process in dynein activation that involves multiple proteins like LIS1.
Article Synopsis
- Intracellular Zn2+ levels rise due to neuronal depolarization, but its immediate effects on neuron function are not well understood.
- Elevated Zn2+ concentrations decrease the movement of lysosomes and mitochondria in primary rat hippocampal neurons and HeLa cells by inhibiting motor proteins without affecting their binding to microtubules.
- Zn2+ binds directly to microtubules and promotes the detachment of specific proteins (like tau and DCX) from them, indicating that Zn2+ plays a crucial role in regulating axonal transport and related microtubule processes.