Publications by authors named "S Marcel"

In this article, we comprehensively evaluate the vulnerability of state-of-the-art face recognition systems to template inversion attacks using 3D face reconstruction. We propose a new method (called GaFaR) to reconstruct 3D faces from facial templates using a pretrained geometry-aware face generation network, and train a mapping from facial templates to the intermediate latent space of the face generator network. We train our mapping with a semi-supervised approach using real and synthetic face images.

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Introduction: Elderly patients are a growing population in stroke units, characterized by higher frailty, but underrepresented in clinical trials about acute care. We investigated efficacy of intravenous thrombolysis (IVT) and mechanical thrombectomy (MT) in elderlies in current practice.

Methods: We assessed consecutive patients with acute ischemic stroke (AIS) hospitalized in the four stroke units of the French Northern Alps Emergency Network between 2015 and 2020.

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Article Synopsis
  • Ewing sarcoma is a cancer primarily affecting children and young adults, driven by the fusion protein EWSR1::FLI1, which disrupts normal chromatin function and gene regulation.
  • Researchers developed a high-throughput screening platform to identify small molecules that can modify chromatin accessibility, leading to the discovery of MS0621, which suppresses the growth of Ewing sarcoma cells through cell cycle arrest.
  • MS0621 was found to interact with both RNA splicing and chromatin regulatory proteins in an RNA-independent manner, suggesting it alters chromatin activity and offers a promising target for future treatments based on chromatin dysregulation mechanisms.
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Chromatin accessibility states that influence gene expression and other nuclear processes can be altered in disease. The constellation of transcription factors and chromatin regulatory complexes in cells results in characteristic patterns of chromatin accessibility. The study of these patterns in tissues has been limited because existing chromatin accessibility assays are ineffective for archival formalin-fixed, paraffin-embedded (FFPE) tissues.

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While preclinical stroke studies have shown that mesenchymal stem cells (MSCs) promote recovery, few randomized controlled trials (RCT) have assessed cell therapy in humans. In this RCT, we assessed the safety, feasibility, and efficacy of intravenous autologous bone marrow-derived MSCs in subacute stroke. ISIS-HERMES was a single-center, open-label RCT, with a 2-year follow-up.

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