Effect of metoprolol and pindolol monotherapy on plasma lipid- and lipoprotein-cholesterol levels (including the HDL subclasses) in mild hypertensive males and females.

Forty-five patients with mild hypertension were treated for 2 months with either metoprolol or pindolol in a randomized, blind, crossover study. The effects of metoprolol (100-300 mg/day) and pindolol (5-15 mg/day) on triglyceride (TG), cholesterol (C), high-density lipoprotein cholesterol (HDL-C), and HDL subfraction (HDL2-C and HDL3-C) levels were compared in males and females separately. Pindolol and metoprolol significantly elevated (10% above baseline level) the plasma TG level in both males and females.

Enzyme induction by o-xylene inhalation.

Inhalation of 4500 mg o-xylene by rats was found to produce adaptational and pathologic changes in the liver by the end of the 1st week, reflected in an increase in relative liver weight, shortening of the hexobarbital sleeping time, an increase in the concentration of cytochrome P-450, with a decrease in the activities of aniline hydroxylase and of aminopyrine N-demethylase. Six weeks after the start of inhalations all the changes in the liver and in the mixed function oxydase system (MFO) were of an adaptational pattern characterized by an increase in relative liver weight as well as in cytochrome P-450 and b5 concentrations, a shortening of the hexobarbital sleeping time and an increase in the activity of aniline hydroxylase and of aminopyrine N-demethylase.

Anion transport of the red cell under non-equilibrium conditions.

1. The exchange of sulphate for chloride across the human red cell membrane was measured in both directions, i.e.