Publications by authors named "S Mansberger"
Purpose: To identify the optimal dose of NCX 470, a nitric oxide (NO)-donating bimatoprost, for comparison to latanoprost in a phase 3 trial for open-angle glaucoma (OAG) or ocular hypertension (OHTN) using an adaptive dose selection design.
Patients And Methods: In this prospective, multicenter trial, subjects were randomized 1:1:1 to NCX 470 0.065 %, NCX 470 0.
Article Synopsis
- The study aims to evaluate how effectively the thickness of different macular retinal layers can differentiate glaucomatous eyes and glaucoma suspects from healthy eyes using optical coherence tomography (OCT).
- The findings reveal that the nerve fiber layer (NFL) and ganglion cell layer (GCL) have the best diagnostic accuracy, with the ganglion cell complex (GCC) performing similarly, while the inner plexiform layer (IPL) is less effective. The combination of NFL or GCL yields the highest sensitivity and overall diagnostic performance.
- The results underscore the necessity of assessing individual retinal layers rather than relying solely on combined metrics, as the best-performing layers can vary based on the specific area of the retina
Purpose: To compare intraocular pressure (IOP)-lowering efficacy and safety of NCX 470, a nitric oxide (NO)-donating bimatoprost, to latanoprost in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).
Design: Prospective, phase 3, randomized, adaptive dose-selection, double-masked, parallel-group trial.
Methods: 691 subjects with OAG or OHT and unmedicated IOP ≥26 mmHg at 8AM, ≥24 mmHg at 10AM, and ≥22 mmHg at 4PM in the study eye were randomized to NCX 470 0.
Prospective cohort study from Brazil to evaluate glaucoma treatment adherence using a medication event monitoring system (MEMS) device and correlate with glaucoma progression and loss to follow-up (LTF) after one year of follow up. We included primary open glaucoma (POAG) patients treated with at least one ocular hypotensive eye drop. MEMS devices was used to monitor adherence for 60 days and evaluate the percentage of doses prescribed taken within the 60-day period.
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