Publications by authors named "S Manolopoulos"

I use the clinical example of a traumatized adolescent to talk about how a transference experience creates the frame where the analytic work occurs. Out of the external boundaries of the relationships with an object, the internal frame, the womb of transformation processes, is created. The analyst's capacity to wait is essential for the transformation that creates and shapes the transference experience, which, like playing, becomes the matrix of the frame where it happens as it happens.

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Objective: Radiotherapy treatment planning relies upon density information provided by CT for accurate dose calculations. Hounsfield units (HUs) are converted to electron/physical density via an energy dependant calibration curve. Multiple curves are required to make full use of the available accelerating potentials (kVp).

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Objectives: Glioblastoma (GBM) is the most common malignant primary brain tumor with local recurrence after radiotherapy (RT), the most common mode of failure. Standard RT practice applies the prescription dose uniformly across tumor volume disregarding radiological tumor heterogeneity. We present a novel strategy using diffusion-weighted (DW-) MRI to calculate the cellular density within the gross tumor volume (GTV) in order to facilitate dose escalation to a biological target volume (BTV) to improve tumor control probability (TCP).

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Article Synopsis
  • Limited visibility of muscle-invasive bladder cancer on CT makes it hard to increase radiation doses, but diffusion-weighted MRI (DW-MRI) could help identify high tumor areas for treatment improvement.
  • This study utilized a bladder phantom to measure DW-MRI distortion compared to CT and T2-weighted MRI, aiming to correct inaccuracies in imaging.
  • Results demonstrated that although DW-MRI distortion was significant (<6 mm), established correction methods reduced discrepancies to under 2 mm, suggesting DW-MRI could improve image-guided radiotherapy for bladder cancer.
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