Publications by authors named "S Maniam"

Article Synopsis
  • Down syndrome (DS) is linked to trisomy 21, leading to intellectual disabilities and increased oxidative stress, impacting neuronal health.
  • REST is a key protein involved in regulating genes related to DS neuropathology, and this study explores lithium’s effects on restoring REST levels in DS neurons.
  • Results indicated that lithium treatment restored nuclear REST levels and significantly reduced reactive oxygen species (ROS) in DS neurons, suggesting potential therapeutic benefits of lithium for improving neuronal function in Down syndrome.
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Medicinal mushrooms, such as Taiwanofungus camphoratus, Inonotus obliquus, and Tropicoporus linteus, have been used in traditional medicine for therapeutic purposes and promotion of overall health in China and many East Asian countries for centuries. Modern pharmacological studies have demonstrated the large amounts of bioactive constituents (such as polysaccharides, triterpenoids, and phenolic compounds) available in these medicinal mushrooms and their potential therapeutic properties. Due to the rising demand for the health-promoting medicinal mushrooms, various cultivation methods have been explored to combat over-harvesting of the fungi.

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Multifunctional heterogeneous catalysts are an effective strategy to drive chemical cascades, with attendant time, resource and cost efficiencies by eliminating unit operations arising in normal multistep processes. Despite advances in the design of such catalysts, the fabrication of proximate, chemically antagonistic active sites remains a challenge for inorganic materials science. Hydrogen-bonded organocatalysts offer new opportunities for the molecular level design of multifunctional structures capable of stabilising antagonistic active sites.

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L. has been traditionally used for treating snakebites and is known to possess antifebrile and hemostatic properties. These properties are closely related to wound healing.

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In recent years, in an effort to reach Net Zero Emissions, there has been growing interest by various academic and industry communities to develop chemicals and industrial processes that are circular, sustainable and green. We report the rapid, simple and effective surface modification of a porous metal oxide with organic dyes using supercritical carbon dioxide (scCO). Titanium dioxide (TiO) photoanodes were coated in very short times, under mild conditions and the excess dye recovered afterwards for reuse.

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