Publications by authors named "S Mangalabharathi"
Objective: To assess feasibility, safety, usability and learnability of delivery room care and resuscitation with intact placental circulation (RIPC) at mother's bedside.
Materials And Methods: We included neonates ≥24 weeks GA after parental consent. Both in vigorous and babies requiring resuscitation, appropriate steps of resuscitation were provided with intact cord till 3 min using RIPC warmer.
Article Synopsis
- A new diagnostic test using whole blood gene analysis may help identify encephalopathic babies at risk of poor neurodevelopmental outcomes within 18 months after birth.
- Researchers performed next-generation sequencing on blood samples from 45 encephalopathic infants, identifying 855 genes with significant differences between those with good and adverse outcomes.
- The findings suggest that transcriptomic profiling could enhance risk assessment in neonatal encephalopathy and reveal potential new treatments for protecting brain health.
Background: Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings. However, the safety and efficacy of cooling therapy in low- and middle-income countries (LMICs), where 99% of the disease burden occurs, remains unclear. We will examine whether whole body cooling reduces death or neurodisability at 18-22 months after neonatal encephalopathy, in LMICs.
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