Publications by authors named "S Mamoei"
Article Synopsis
- A 1-year study compared individuals with multiple sclerosis (PwMS) who responded to Fampridine treatment versus those who did not, looking at various disability measures and performance tests.
- The study included tests like the timed 25-foot walk and symbol digit modalities test, finding prolonged peripheral motor conduction times in non-responders, but no significant differences in other tests.
- Central motor conduction times were linked to disability status, while cognitive performance was associated with MRI-visible brain lesions, suggesting the potential use of these measures to track progression in MS.
Article Synopsis
- The study aimed to compare physical and cognitive performance, neurophysiological outcomes, and MRI results between participants with Multiple Sclerosis who responded or did not respond to Fampridine treatment.
- Despite assessing 41 responders and 8 non-responders, no significant differences were found in any measured outcomes between the two groups.
- However, certain associations were noted, such as the connection between central motor conduction time (CMCT) and various performance measures, as well as the relationship between the Symbol Digit Modalities Test (SDMT) and T2-weighted MRI lesions, highlighting potential markers for disability and walking impairment.
A systematic review of the literature was conducted comparing neurophysiological outcomes in persons with multiple sclerosis (PwMS) to healthy controls (HC), in studies of the central nervous system (CNS) function comprising motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) and in studies of the peripheral nervous system (PNS) function comprising electroneuronography (ENG) outcomes elicited by peripheral nerve stimulation. Studies comparing neuromuscular function, assessed during maximal voluntary contraction (MVC) of muscle, were included if they reported muscle strength along with muscle activation by use of electromyography (EMG) and/or interpolated twitch technique (ITT). Studies investigating CNS function showed prolonged central motor conduction times, asymmetry of nerve conduction motor pathways, and prolonged latencies in PwMS when compared to HC.
View Article and Find Full Text PDFCase: The authors describe the case of an 8-year-old boy with pansynostosis in the context of Albright's hereditary osteodystrophy (AHO). This condition had lead to raised intracranial pressure (ICP). The elevated ICP was a consequence of the rigid skull impeding brain growth.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to estimate the minimal clinically important difference (MCID) in cognition and functional capacity for people with multiple sclerosis (PwMS) after treatment with slow release fampridine.
- Researchers evaluated 105 PwMS using various tests, including walking speed and hand dexterity, to determine MCID values for several functional assessments.
- The findings established specific MCID values for tests like the Timed 25 Foot Walk and the 5-Time Sit-To-Stand, providing useful benchmarks for clinicians assessing treatment effectiveness in PwMS.